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이여진 ( Lee Yeo-Jin ) - Yonsei University College of Medicine Department of Obstetrics and Gynecology
윤지선 ( Yoon Ji-Sun ) - National Health Insurance Service Ilsan Hospital Department of Obstetrics and Gynecology
김영근 ( Kim Young-Keun ) - Yonsei University Wonju College of Medicine Department of Internal Medicine
김의혁 ( Kim Eui-Hyeok ) - National Health Insurance Service Ilsan Hospital Department of Obstetrics and Gynecology
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Abstract
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Purpose: To determine the clinical manifestations and maternal and perinatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19).
Methods: We conducted a retrospective observational study of pregnant women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection who were admitted to National Health Insurance Service (NHIS) Ilsan Hospital between August 2020 and October 2021. The maternal and perinatal outcomes were investigated.
Results: Among 184 pregnant women infected with SARS-CoV-2, 79 women delivered. Of the women who delivered, with 36 women giving birth during the quarantine period. At delivery, 45 women were positive for SARS-CoV-2 by polymerase chain reaction (PCR), whereas 34 women were negative. The most common clinical manifestations were cough (65.2%), fever (38.0%), and myalgia (33.2%). Regarding perinatal outcomes, none of the babies had an Apgar score < 7 at 5 minutes, and none were intubated following the delivery. The preterm birth rate and small-for-gestational-age (SGA) rate were 15.2% and 16.5%, respectively. All babies who was delivered at NHIS Ilsan Hospital were negative for SARSCoV- 2 infection by PCR, which was evaluated using amniotic fluid, cord blood, neonatal nasopharyngeal and oropharyngeal swabs in the 1st and 2nd days following delivery, although 45 women were positive for SARS-CoV-2 infection by PCR at the time of delivery.
Conclusion: Most pregnant women with COVID-19 in South Korea were unlikely to manifest symptoms or present with a severe disease progression. The observed preterm birth rate and SGA rate were higher in women with COVID-19 than in those without COVID-19. However, there was no evidence of vertical transmission, and all babies were negative for SARS-CoV-2 infection during pregnancy.
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KeyWords
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SARS-CoV-2 Infection, Maternal and perinatal outcomes
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원문 및 링크아웃 정보
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등재저널 정보
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